The ERBB3 Antibody (N-term) from MyBioSource.com is a Rabbit Polyclonal antibody to c-erbB-3, c-erbB3, ERBB3, and HER3. This antibody recognizes Human, and Mouse antigen. The ERBB3 Antibody (N-term) has been validated for the following applications: ELISA, Flow Cytometry, Immunohistochemistry, and Western Blot.
Description
ErbB3, a member of the EGF receptor family, binds and is activated by neuregulins and NTAK. It potentially forms a heterodimer with each of the other ERBB receptors. This protein is predominantly expressed in epithelial tissues and brain. The cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing proteins. Ligand-binding may increase phosphorylation on tyrosine residues and promote its association with the p85 subunit of phosphatidylinositol 3-kinase ErbB3 is overexpressed in a subset of human mammary tumors